Robust Trans-Amide Helical Structure of Oligomers of Bicyclic Mimics of β-Proline: Impact of Positional Switching of Bridgehead Substituent on Amide Cis-Trans Equilibrium.
Siyuan Wang; Yuko Otani; Xin Liu; Masatoshi Kawahata; Kentaro Yamaguchi; Tomohiko Ohwada Journal of Organic Chemistry, 2014, 79 (11), pp 5287-5300.
Abstract
Secondary Structure of Homo-thiopeptides Based on a Bridged β-Proline Analogue: Preferred Formation of Extended Strand Structures with Trans-Thioamide Bonds
Yuko Otani, Tetsuharu Hori, Masatoshi Kawahata, Kentaro Yamaguchi and Tomohiko Ohwada Tetrahedron, 2012，68 (23), 4418-4428
Special Issue (Symposium in print) on Chemistry of Foldamers
Abstract
Water-stable Helical Structure of Tertiary Amides of Bicyclic β-Amino Acid Bearing 7-Azabicyclo[2.2.1]heptane. Full Control of Amide Cis-Trans Equilibrium by Bridgehead Substitution.
Masahiro Hosoya; Yuko Otani; Masatoshi Kawahata; Kentaro Yamaguchi; Tomohiko Ohwada Journal of the American Chemical Society, 2010, 132, 42, 14780-14789.
Abstract
Nonplanar Structures of Thioamides Derived from 7-Azabicyclo[2.2.1]heptane. Electronically Tunable Planarity of Thioamides
Hori, T.; Otani, Y.; Kawahata, M.; Yamaguchi, K.; Ohwada, T. Journal of Organic Chemistry,2008, 73, 9102-9108.
Abstract
alpha,alpha-Disubstituted Amino Acids Bearing a Large Hydrocarbon Ring. Peptide Self-Assembly through Novel Hydrophobic Recognition
Ohwada, T.; Kojima, D.; Kiwada, T.; Futaki, S.; Sugiura, Y.; Yamaguchi, K.; Nishi, Y.; Kobayashi, Y. Chemistry-A European Journal, 2004, 10, 617-626.
Abstract
An Evaluation of Amide Group Planarity in 7-Azabicyclo[2.2.1]heptane Amides. Low Amide Bond Rotation Barrier in Solution.
Yuko Otani; Osamu Nagae; Yuji Naruse; Satoshi Inagaki; Masashi Ohno; Kentaro Yamaguchi; Gaku Yamamoto; Masanobu Uchiyama; Tomohiko Ohwada Journal of the American Chemical Society, 2003, 125, 15191-15199.
Abstract
非平面ニトロソアミンの化学 Ｓ−ニトロシル化とＮＯ発生と生物機能調整
Non-planar N-Nitrosamine Chemistry and Biological Relevance
Attenuated Desensitization of β-Adrenergic Receptor by Water-Soluble N-Nitrosamines That Induce S-Nitrosylation Without NO Release
Noriko Makita, Yoji Kabasawa, Yuko Otani, Firman, Junichiro Sato, Makiko Hashimoto, Michio Nakaya, Hiroaki Nishihara, Masaomi Nangaku, Hitoshi Kurose, Tomohiko Ohwada and Taroh Iiri Circulation Research, 2013, 112, 327-334.
Abstract
Visible-light-triggered Release of Nitric Oxide from N-Pyramidal Nitrosamines
Fumika Karaki, Yoji Kabasawa, Takahiro Yanagimoto, Nobuhiro Umeda, Firman, Yasuteru Urano, Tetsuo Nagano, Yuko Otani, and Tomohiko Ohwada Chemistry - A European Journal, 2012, 18 (4), 1127-1141.
Abstract
7-Azabicyclo[2.2.1]heptane as a Structural Motif to Block Mutagenicity of Nitrosamines
Tomohiko Ohwada, Satoko Ishikawa, Yusuke Mine, Keiko Inami, Takahiro Yanagimoto, Fumika Karaki, Yoji Kabasawa, Yuko Otani, Masataka Mochizuki Bioorganic & Medicinal Chemistry, 2011, 19, 2726-2741.
Abstract
Transnitrosation of Thiols from Aliphatic N-Nitrosamines: S-Nitrosation and Indirect Generation of Nitric Oxide
Yanagimoto, T.; Toyoda, T.; Matsuki, N.; Makino, Y.; Uchiyama, S.; Ohwada, T. Journal of the American Chemical Society, 2007, 129, 736-737.
Abstract
Structural Features of Aliphatic N-Nitrosamines of 7-Azabicyclo[2.2.1]heptanes That Facilitate N-NO Bond Cleavage
Tomohiko Ohwada,Motoko Miura, Haruko Tanaka, Shigeru Sakamoto, Kentaro Yamaguchi, Hirotaka Ikeda, and Satoshi Inagaki Journal of the American Chemical Society, 2001, 123, 10164-10172.
Abstract
芳香族官能基化反応の開発 超求電子体の化学Aromatic Functionalized
Reactions Involving Dicationic and Monocationic Superelectrophiles
Acid-promoted Chemoselective Introduction of Amide Functionality onto Aromatic Compounds Mediated by Isocyanate Cation Generated from Carbamate.
Akinari Sumita, Hiroaki Kurouchi, Yuko Otani, Tomohiko Ohwada Chemistry - An Asian Journal, 2014, 9 (10), 2995–3004.
Abstract
Protonation Switching to Least Basic Heteroatom of Carbamate through Cationic Hydrogen Bonding Promotes Formation of Isocyanate Cation
Hiroaki Kurouchi, Akinari Sumita, Yuko Otani, Tomohiko Ohwada Chemistry - A European Journal, 2014, 20, 8682-8690.
Abstract
Cyclization of Arylacetoacetates to Indene and Dihydronaphthalene Derivatives in Strong Acid. Evidenece for Involvement of Further Protonation of O,O-Diprotonated beta-Ketoester, Leading to Enhancement of Cyclization
Hiroaki Kurouchi, Hiromichi Sugimoto, Yuko Otani, Tomohiko Ohwada Journal of the American Chemical Society, 2010, 132, 807-815.
Abstract
Superacid-catalyzed Intramolecular Cyclization Reaction of Arylcyanopropionate: Geminal Substitution Effect on Superelectrophilicity
Nakamura, S.; Sugimoto, H.; Ohwada, T. Journal of Organic Chemistry,2008, 73(11), 4219-4224.
Abstract
Formation of 4H-1,2-Benzoxazines by Intramolecular Cyclization of Nitroalkanes. Scope of Aromatic Oxygen-functionalization Reaction Involving a Nitro Oxygen Atom, and Mechanistic Insights
Nakamura, S.; Sugimoto, H.; Ohwada, T. Journal of the American Chemical Society,2007, 129, 1724-1732.
Abstract
Generation and Application of o-Benzoquinone Methides Bearing Various Substituents on the Benzene Ring.
Sugimoto, H.; Nakamura, S.; Ohwada, T. Advanced Synthsis & Catalysis, 2007, 349, 669-679.
Abstract
The Prototype Pictet-Spengler Reactions Catalyzed by Superacids. Involvement of Dicationic Superelectrophiles
Yokoyama,A.; Ohwada, T.; Shudo, K. Journal of Organic Chemistry,1999, 64, 611-617.
Abstract
Superacid-catalyzed Electrocyclization of Diphenylmethyl Cations to Fluorenes. Kinetic and Theoretical Revisit Supporting the Involvement of Ethylene Dications
Ohwada, T;Suzuki, T.; Shudo, K. Journal of the American Chemical Society, 1998, 120, 4629-4637.
Abstract
膜タンパク質の機能を調整する有機分子のデザインと合成Design and Synthesis of
Membrane Protein Function Modulators. Mechanistic Interests.
Discovery of a Tamoxifen-related compound that suppresses glial L-glutamate transport activity without interaction with estrogen receptors"
Kaoru Sato , Jun-ichi Kuriwaki, Kanako Takahashi, Yoshihiko Saito, Jun-ichiro Oka, Yuko Otani, Yu Sha, Ken Nakazawa, Yuko Sekino, Tomohiko Ohwada ACS Chemical Neuroscience, 2012, 3, 105-113.
Abstract
Molecular mechanism of pharmacological activation of BK channels
Guido Gessner, Yong-Mei Cui, Yuko Otani, Tomohiko Ohwada, Malle Soom, Toshinori Hoshi, and Stefan H. Heinemann Proceedings of the National Academy of Sciences of the U. S. A. 2012, 109 (9) 3552-3557.
Abstrct
Synthesis and Evaluation of Lysophosphatidylserine Analogs as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidyl- threonine and Its 2-Deoxy Derivative
Masazumi Iwashita, Kumiko Makide, Taro Nonomura, Yoshimasa Misumi, Yuko Otani, Mayuko Ishida, Ryo Taguchi, Masafumi Tsujimoto, Junken Aoki, Hiroyuki Arai, Tomohiko Ohwada Journal of Medicinal Chemistry, 2009, 52 (19), 5837-5863.
Abstract
Design, Synthesis and Characterization of BK Channel Openers Based on Oximation of Abietane Diterpene Derivatives
Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Katsutoshi Ido, Takashi Yoshinaga, Kohei Sawada, and Tomohiko Ohwada Bioorganic & Medicinal Chemistry, 2010, 18, 8642-8659.
Abstract
Novel Oxime and Oxime Ether Derivatives of 12,14-Dichlorodehydroabietic Acid: Design, Synthesis and BK Channel-Opening Activity
Cui, Y.-M.; Yasutomi, E.; Otani, Y.; Yoshinaga, T.; Ido, K.; Sawada, K. Kawahata, M. ; Yamaguchi, K.; Ohwada, T. Bioorganic & Medicinal ChemistryLetters, 2008, 18 (24), 6386-6389.
Abstract
Theoretical study on the excited states of heteroarene chromophores: Comparison of calculated and experimental values
Tsuji, T.; Onoda, M.; Otani, Y.; Ohwada, T.; Nakajima, T.; Hirao, K. Chemical Physics Letters, 2009, 473 (1-3), 29, 196-200
Abstract
Theoretical Revisit of Regioselectivities of Diels-Alder Reactions. Quantitative Evaluation of Multicentered Reactivity Based on Reactive Hybrid Orbitals
Hirao, H. ; Ohwada, T. Journal of Physical Chemistry A.2005, 109, 816-824.
Abstract
Rationale for the Acidity of Meldrum's Acid. Consistent Relation of C-H Acidities to the Properties of Localized Reactive Orbital
Nakamura, S.; Hirao, H.; Ohwada, T. Journal of Organic Chemistry, 2004, 69, 4309-4316.
Abstract
